hyperinflammatory state – Communicable Diseases Research

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

SARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경

Article

Published on 2022-12-012022-09-11
Journal: Protein & Cell
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

Comparable bidirectional neutrophil immune dysregulation between Kawasaki disease and severe COVID-19

Article

Published on 2022-09-082022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] 24 hour acute respiratory syndrome aged neutrophils analyses bidirectional children Clustering comparable Control controls coronavirus COVID-19 Critical demonstrated downloaded dysregulation enrolled expression Fever functional gene cluster Health Hierarchical hyperinflammatory state immune dysregulation Inflammatory Influenza Kawasaki disease mechanisms MHC class neutrophil neutrophil activation neutrophilic nuclei occur overactivation overlapping Patient performed Potential treatment reduction representing SARS-CoV-2 Sequence Read Archive severe COVID-19 Single-cell RNA sequencing single-cell RNA sequencing. syndrome target Treatment
[DOI] 10.3389/fimmu.2022.995886 PMC 바로가기

SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients

SARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다

Article

Published on 2022-08-172022-09-11
Journal: Journal of Molecular Cell Biology
[Category] SARS, 진단, 치료기술, 치료법,

[키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood peripheral blood mononuclear cell (PBMC). Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread
[DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article

Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort

스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성

Article

Published on 2022-08-122022-09-11
Journal: PLoS ONE
[Category] SARS, 유전자 메커니즘,

[키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin
[DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article

Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients

NF-κB 신호 전달 경로(NFKB1, NFKBIA, NFKBIZ)의 유전적 변이와 COVID-19 환자의 중대한 결과 위험

Article

Published on 2022-08-012022-09-11
Journal: Human immunology
[Category] COVID19(2023년), SARS, 변종,

[키워드] Cohort component Control COVID-19 COVID-19 patient Critical D-dimer value Deceased explain form Gene polymorphisms genetic association Genetic variation Genotype healthy Homozygosis hyperinflammatory state ICU ICU admission implicated Inflammation insertion lower expression mice Mortality NF-κB NF-κB signaling NF-κB signaling pathway NFkB1 NFKBIA NFKBIZ NFKBIZ. outcome pathway Patient patients populations predisposition RATs Respiratory Support risk risk of death SARS-COV-2 infection Sepsis severe COVID-19 severe forms of COVID-19 significant effect Spanish patient Survivors the patient total blood transcript variant variants viral disease was increased
[DOI] 10.1016/j.humimm.2022.06.002 PMC 바로가기 [Article Type] Article

Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients

혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다

Article

Published on 2022-07-192022-09-11
Journal: Frontiers in Immunology
[Category] 유전자 메커니즘,

[키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcription factors. transcriptomic data Unsupervised clustering upstream worse prognosis
[DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article

Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes

임상적으로 승인된 약물인 클로르프로마진, 인간 단핵구에서 SARS-CoV-2 뉴클레오캡시드 매개 IL-6 유도 억제

Article

Published on 2022-06-072022-09-11
Journal: Molecules
[Category] COVID19(2023년), SARS, 치료법,

[키워드] activated Acute respiratory failure Affect Antiviral caused chlorpromazine Course COVID-19 COVID-19 pandemic COVID-19 symptom COVID-19 symptoms creating cytokine Cytokine storm Cytokines drug expression human monocyte hyperinflammatory state IL-6 immunomodulatory activity in some induction inhibit interleukin interleukin 6 macrophages monocyte Monocytes monocytes. neuroleptic NF-κB nucleocapsid protein overcome patients with COVID-19 Pneumonia proinflammatory Respiratory failure resulting Safe SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus nucleocapsid protein secreted secretion Severe infection severe infections Signaling Support target the disease therapy Vaccine
[DOI] 10.3390/molecules27123651 PMC 바로가기 [Article Type] Article

Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19

Research article

Published on 2022-06-012022-10-05
Journal: Medical Hypotheses
[Category] 변종, 유전자 메커니즘,

Inflammasome activation in infected macrophages drives COVID-19 pathology

감염된 대식세포의 인플라마좀 활성화는 COVID-19 병리를 유발합니다

Article

Published on 2022-06-012022-09-12
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] ACE2 receptors activate Activation antibody attenuate blockade blocking cascade CD16 characterized contributing to COVID-19 COVID-19 pathology Critical disease downstream host infection Human immune system human macrophage humanized hyperinflammatory state IFN IL-1 IL-18 immune in vivo Infection Infectious virus Inflammasome inflammasome activation inflammasomes Inflammatory cytokine inflammatory cytokine production inflammatory macrophages Inflammatory response interferon Lung inflammation Lung pathology Lungs Macrophage macrophages NLRP3 inflammasome overactive pathology pathway Prevent pyroptosis Remdesivir Replication required SARS-CoV-2 SARS-COV-2 infection Stage sustained undergo viral replication Viral RNA
[DOI] 10.1038/s41586-022-04802-1 PMC 바로가기 [Article Type] Article

Impact of renin–angiotensin–aldosterone system inhibitors on COVID-19

Reviews

Published on 2022-05-182022-10-05
Journal: Hypertension research : official journal of the Ja
[Category] COVID19(2023년), SARS, 임상,